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02/02/2008: ISS Announces 2008 Gregorio Weber Award Winner
06/06/2007: ISS Awarded NIH Grant
03/03/2007: ISS Announces 2007 Gregorio Weber Award Winner
02/18/2006: ISS Announces 2006 Gregorio Weber Award Winner
09/01/2005: ISS Achieves ISO 9001:2000 Certification
01/05/2005: ISS Announces a New Version of OxiplexTS™
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06/06/2007: ISS Awarded NIH Grant
03/03/2007: ISS Announces 2007 Gregorio Weber Award Winner
02/18/2006: ISS Announces 2006 Gregorio Weber Award Winner
09/01/2005: ISS Achieves ISO 9001:2000 Certification
01/05/2005: ISS Announces a New Version of OxiplexTS™
News Archive
Fluorescence Products
Alba FCS: Fluorescence Correlation SpectrometerAlba FLIM: Fluorescence Lifetime Imaging
PC1: Photon Counting Spectrofluorimeter
K2: Multifrequency Cross-Correlation Phase and Modulation Fluorometer
Chronos: Frequency-Domain Lifetime Spectrometer
ChronosBH: Time-Domain Lifetime Spectrometer
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Phoenix: SLM Upgrade Packages
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Fluorescence Lifetime Standards
Lifetime Data of Selected Fluorophores
Excitation and Emission Wavelengths of Fluorophores
Fluorescent Probes Data Table
Fluorescence Standards for LEDs and Laser Diodes
Application & Technical Notes
Measurement Examples
Selected Publications
Laboratories & Societies
Imagent™ Bibliography
Comparison Between Imagent™ and fMRI
- V. Toronov, E. Gratton, and A. Webb; “Simultaneous Near-Infrared Spectroscopy and Magnetic Resonance Imaging of Functional Activity in the Human Brain”; in “Res. Adv. in Medical Physics”, R.M. Mohan ed., 1, 1-15, Global Research Network (2003)
- V. Toronov, A. Webb, S. Walker, R. Gupta, J.H. Choi, E. Gratton, and D. Hueber; “The Roles of Changes in Deoxyhemoglobin Concentration and Blood Volume in the fMRI BOLD Signal”; Neuroimage, 19, 1521-1531 (2003).
- V. Toronov, A. Webb, J. H. Choi, M. Wolf, A. Michalos, E. Gratton and D. Hueber; “Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging”; Medical Physics 28(4), 521-527 (2001).
- V. Toronov, A. Webb, J. H. Choi, M. Wolf, E. Gratton and D. Hueber, “Simultaneous functional magnetic resonance and near-infrared imaging of adult human brain”, In Proc. SPIE Vol. 4250, 380-382 (2001)
- Toronov, V., A. Webb, J. H. Choi, M. Wolf, L. Safonova, U. Wolf, and E. Gratton; “Study of Local Cerebral Hemodynamic Fluctuations by Simultaneous Frequency-Domain near-infrared spectroscopy and fMRI”; Optics Express 9(8), 417-427 (2001).
Brain Imaging (slow signals) on Humans
- Jee Hyun Choi, Martin Wolf, Vlad Toronov, Ursula Wolf, Chiara Polzonetti, Dennis Hueber, Larisa P. Safonova, Rajarsi Gupta, Antonios Michalos, William Mantulin, and Enrico Gratton;“Noninvasive determination of the optical properties of adult brain: Near infrared spectroscopy approach”; J Biomed Opt. 9(1): 221-9 (2004).
- Wolf M., Wolf U., Choi J.H., Toronov V., Paunescu L.A, Michalos A., Gratton E.; “Fast cerebral functional signal in the 100ms range detected in the visual cortex by frequency-domain near-infrared spectroscopy”; Psychophysiology, 40, 521-528 (2003).
- Wolf, M., M. A. Franceschini, L. A. Paunescu, V. Toronov, A. Michalos, U. Wolf, E. Gratton, and S. Fantini; “Absolute frequency-domain pulse oximetry of the brain: Methodology and measurements”; Adv. Exp. Med. Biol. 530, 61-73 (2003).
- Wolf, M., Wolf, U., Toronov, V., Michalos, A., Paunescu, L.A., Choi, J.H., and Gratton E.; “Different Time Evolution of Oxyhemoglobin and Deoxyhemoglobin Concentration Changes in the Visual and Motor Cortex during Functional Stimulation: A near Infrared Spectroscopy Study”; Neuroimage, 16, 704-712 (2002).
- M.A. Franceschini, V. Toronov, M. Filiaci, E. Gratton and S. Fantini; “On-line optical imaging of the human brain with 160-ms temporal resolution”; Optics Express 6, 49-57 (2000).
- Toronov, V., M. A. Franceschini, M. Filiaci, S. Fantini, M. Wolf, A. Michalos, and E. Gratton; “Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Temporal analysis and spatial mapping”; Med. Phys. 27(4), 801-815 (2000).
- Franceschini, M. A., V. Toronov, M. Filiaci, E. Gratton, and S. Fantini; “On-line optical imaging of the human brain with 160-ms temporal resolution”; Optics Express 6(3), 49-57 (2000).
- Franceschini, M.A., V. Toronov, M. E. Filliaci, M. Wolf, A. Michalos, E. Gratton, and S. Fantini. Real-time video of cerebral hemodynamics in the human brain using non-invasive optical imaging. Neuroimage 11(5) S454 (2000).
- M.A. Franceschini, S. Fantini, V. Toronov, M. E. Filiaci, and E. Gratton, “Cerebral hemodynamics measured by near-infrared spectroscopy at rest and during motor activation”, In Proc. Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, A. Ganjbakhche ed.,(Optical society of America, Washington DC) pp. 73-80 (1999).
- Wolf, M., U. Wolf, V. Toronov, L. A. Paunescu , A. Michalos, M. A.Franceschini , S. Fantini, and E. Gratton. Fast cerebral functional signals in the 100 ms range detected by frequency-domain near-infrared spectroscopy. Neuroimage 11(5) S515 (2000).
Sensory and Working Memory in Aging
- Sable, J.J., Low, K.A., Maclin, E.L., Fabiani, M., and Gratton, G.; “Latent Inhibition Mediates N1 Attenuation to Repeating Sounds,”; Psychophysiology (In press).
- Fabiani, M.; “Multiple Electrophysiological Indices of Distinctiveness,” in “Distinctiveness and Memory”, R.R. Hunt and J.B. Worthen, eds., Cambridge, MA; Oxford University Press (In press).
- Fabiani, M., & Gratton, G.; “Electrophysiological and Optical Measures of Cognitive Aging,” in “Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging”, R. Cabeza, L. Nyberg, and D. Park, eds.; Oxford University Press (In press).
- Brumback, C.R., Low, K.A., Gratton, G. and Fabiani, M.; “Sensory Brain Responses Predict Individual Differences in Working Memory Span and Fluid Intelligence,” NeuroReport, 15/2, pp. 373-376 (2004).
- Rinne T., G. Gratton, M. Fabiani, N. Cowan, E. Maclin, A. Stinard, J. Sinkkonen, K. Alho, and Risto Näätänen; “Scalp-Recorded Optical Signals Make Sound Processing in the Auditory Cortex Visible”, NeuroImage 10, 620-624 (1999).
Fast Signals (EROS: Event Related Optical Signal)
- Gratton G., M. Fabiani, D. Friedman, M. A. Franceschini, S. Fantini, P. M. Corballis, and E. Gratton; “Rapid Changes of Optical Parameters in the Human Brain During a Tapping Task”, J. Cognitive Neuroscience 7, 446-456 (1995).
- Gratton G., P. M. Corballis, E. Cho, M. Fabiani, and D. C. Hood; “Shades of gray matter: non-invasive optical images of human brain responses during visual stimulation”, Psychophysiology 32, 505-509 (1995).
- Gratton G. and M. Fabiani; “Dynamic brain imaging: Event-related optical signal (EROS) measures of the time course and localization of cognitive-related activity”, Psychonomic Bulletin & Review 5, 535-563 (1998).
- Gratton G., M. Fabiani, M.R. Goodman-Wood, and M.C. DeSoto; “Memory-driven processing in human medial occipital cortex: An event-related optical signal (EROS) study”, Psychophysiology 35, 348-351 (1998).
- Gratton G., A. Sarno, E. Maclin, P. M. Corballis, and M. Fabiani; Neuroimage 11, 491-504 (2000).
- Gratton, G. & Fabiani, M.; “Non-invasive Fast Optical Imaging in Humans,” Scattered Light Imaging of Brain Function for the Contemporary Clinical Neuroscience Series, in D.M. Rector and J.S. George, eds., Totowa, NJ: Humana Press. (In press),
- Maclin, E.L., Low, K.A., Sable, J.J., Fabiani M., and Gratton, G.; “The Event Related Optical Signal (EROS) to Electrical Stimulation of the Median Nerve,” NeuroImage. (In press),
Animals studies
- S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, and M. R. Stankovic; Non-invasive Optical Monitoring of the Newborn Piglet Brain Using Continuous-wave and Frequency-domain Spectroscopy; Phys. Med. Biol., 44 (1999) 1543-1563.
- S. Fantini, M.A. Franceschini, E. Gratton, D. Hueber, W. Rosenfeld, D. Maulik, P. Stubblefield, and M.R. Stankovic; Non-invasive optical mapping of the piglet brain in real time; Optics Express. 4(8), (1999) 308-314. ).
- D. M. Hueber, M A. Franceschini, H. Y. Ma, Q. Zhang, J. R. Ballesteros, S. Fantini, D. Wallace, V. Ntziachristos and B. Chance; Non-invasive and quantitative near-infrared hemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multi-distance instrument; Submitted to Physics in Medicine and Biology, (June 2000).
- M.R. Stankovic, D. Maulik, W. Rosenfeld, P.G. Stubblefield, A.D. Kofinas, S. Drexler, R. Nair, M.A. Franceschini, D. Hueber, E. Gratton, and S. Fantini; Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets; J. of Perinatal Medicine. 27(4), (1999) 279-286.

